HDRF was founded in April 2006 by Audrey Gruss in honor of her mother, Hope, who suffered from clinical depression. Its mission is to fund cutting-edge, international scientific research into the origins, diagnosis, treatment and prevention of depression and its related mood disorders – anxiety, bipolar disorder, postpartum depression, prolonged grief and posttraumatic stress syndrome – with the ultimate goal of finding a cure.

HDRF sets itself apart by funding a pioneering research approach. The foundation recognizes the need to combine the study of both the brain and the mind by supporting research that integrates the fields of neuroscience (the brain) and psychology (the mind). While this research is HDRF’s priority, the Foundation also funds the most rapidly-emerging fields of neuroscience that hold the greatest possibility for breakthrough discoveries – genetics and epigenetics, neuroanatomy, neurochemistry and neurophysiology.

HDRF is a 501 (c)(3) public charity and is obligated to raise public funds to support its mission. The Audrey and Martin Gruss Foundation underwrites all of HDRF’s administrative expenses, so that every dollar raised goes directly to research.



We want to hear from you! Your questions, comments and concerns are important to us.

New York Office:
Hope for Depression Research Foundation
667 Madison Avenue, 2nd Floor
New York, NY 10065

Tel: 212-446-4235
Fax: 212-901-0912
Email: hdrf@hopefordepression.org

Palm Beach Office:
Hope for Depression Research Foundation
777 S. Flagler Drive
Suite 801 E
West Palm Beach, FL 33401

Tel: 561-514-3295
Fax: 561-514-3520
Email: sm@hopefordepression.org