HDRF-funded Research Publications

From its initial grant cycle in January 2007, HDRF has awarded 104 research grants at 48 leading domestic and international institutions. These grants have yielded a wide range of valuable research results which have been published in leading peer-reviewed scientific journals. Below are the highlights of important new findings which are the result of grants funded by HDRF.


Treating Depression at the Source: Electrical Stimulation Deep within the Brain may Alleviate Devastating Mood Disorders. Scientific American. 2015. (Lozano, Andres M. and Mayberg, Helen S.)


Maternal care differentially affects synaptic plasticity in the dorsal and ventral hippocampus. (In press) Neuropsychopharmacology. (Nguyen H-B, Bagot RC, Diorio J, Wong TP, Meaney MJ.)

BDNF Val66Met polymorphism influences the association of the methylome with maternal anxiety and neonatal brain volumes. (In press) Development and Psychopathology. (Li C, Pan H, Tuan TA, Teh AL, Mah SM, Li Y, Cehn H, Broekman BFP, Buschdorf JP, Chong YS, Kwek K, Saw SM, Gluckman PD, Fortier MV, Rifkin-Graboi A, Kobor MS, Qiu A, Meaney MJ, Holbrook JD)

Brain-derived neurotrophic factor (BDNF) in the nucleus accumbens mediates individual differences in behavioral responses to a natural, social reward. (Under review) Nature Neuroscience. (Shahrokh D, Ian C. Hellstrom IC, Josie C. Diorio J, Christian Caldji C, Meaney MJ)

Defining Critical White Matter Pathways Mediating Successful Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression. Biological Psychiatry. 2014. (Riva-Posse, P., Choi, K.S., Holtzheimer, P.E., McIntyre, C.C., Gross, R.E., Chaturvedi, A., Crowell, A.L., Garlow, S.J., Rajendra, J.K., Mayberg, H.S.)

Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility. Molecular Psychiatry. 2014. (C Nasca, B Bigio, D Zelli, F Nicoletti, and BS McEwen)

Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat Neurosci 17:106-113. 2014. (Likhtik, E., J.M. Stujenske, M. Topiwala, A.Z. Harris, and J.A. Gordon.)

Epigenetic signaling in psychiatric disorders. Molecular Biology, in press. 2014. (Pena CJ, Bagot RC, Labonté B, Nestler EJ)

Epigenetic mechanisms in depression. Dialogues Clinical Neuroscience, in press. 2014. (Bagot RC, Labonté B, Pena CJ, Nestler EJ)

Hippocampal HDAC4 contributes to postnatal fluoxetine-evoked depression-like behavior. Neuropsychopharmacology, in press. 2014. (Sarkar A, Chachra P, Kennedy P, Pena CJ, Desouza LA, Nestler EJ, Vaidya VA)

Dendritic inhibition in the hippocampus supports fear learning. Science. 343(6173):857-63. 2014. (Lovett-Barron M, Kaifosh P, Kheirbek MA, Danielson N, Zaremba JD, Reardon TR,  Turi GF, Hen R, Zemelman BV, Losonczy A.)

Functional dissociation of adult-born neurons along the dorsoventral axis of the dentate gyrus. Hippocampus. 2014. (Wu MV, Hen R)

From Psychiatric Disorders to Animal Models: A Bidirectional and Dimensional Approach. Biological Psychiatry. 2014. (Donaldson ZR, Hen R)

Impact of Social Status and Antidepressant Treatment on Neurogenesis in the Baboon Hippocampus. Neuropsychopharmacology. 2014. (Wu MV, Shamy JL, Bedi G, Choi CW, Wall MM, Arango V, Boldrini M, Foltin RW, Hen R.)

Global state measures of the dentate gyrus gene expression system predict antidepressant-sensitive behaviors. PLoS One. 2014. (Samuels BA, Leonardo ED, Dranovsky A, Williams A, Wong E, Nesbitt AM, McCurdy RD, Hen R, Alter M)


Hippocampal gene expression changes underlying stress sensitization and recovery. Molecular Psychiatry (2013), 1–8. (JD Gray, TG Rubin, RG Hunter and BS McEwen)

Rapid Anxiolytic Effects of a 5-HT(4) Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism. Neuropsychopharmacology. 2013. (Mendez-David I, David DJ, Darcet F, Wu MV, Kerdine-Römer S, Gardier AM, Hen R.)

Developmental Effects of Serotonin 1A Autoreceptors onAnxiety and Social Behavior. Neuropsychopharmacology. 2013 Aug 2 (Donaldson ZR, Piel DA, Santos TL, Richardson-Jones J, Leonardo ED, Beck SG,Champagne FA, Hen R.)

Add neurons, subtract anxiety. Scientific American (in press). 2013. (Kheirbek MA, Hen R)

Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn Mem. 19;20(12):710-29. 2013. (Drew LJ, Fusi S, Hen R.)

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 73:147-59. 2013. (Guilloux JP, Mendez-David I, Pehrson A, Guiard BP, Repérant C, Orvoën S, Gardier AM, Hen R, Ebert B, Miller S, Sanchez C, David DJ.)

Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science. 340(6137):1234-9. 2013. (Ahmari SE, Spellman T, Douglass NL, Kheirbek MA, Simpson HB, Deisseroth K, Gordon JA, Hen R.)

(Radio)active neurogenesis in the human hippocampus. Cell. 153(6):1183-4. 2013. (Kheirbek MA, Hen R)

Genetic approaches for understanding the role of serotonin receptors in mood and behavior. Curr Opin Neurobiol. 23(3):399-406. 2013. (Donaldson ZR, Nautiyal KM, Ahmari SE, Hen R.).

Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology. 38(6):1068-77. 2013. (Boldrini M, Santiago AN, Hen R, Dwork AJ, Rosoklija GB, Tamir H, Arango V, John Mann J)

Neuronal plasticity and antidepressant actions. Trends Neurosci. 36(5):259-67. 2013. (Castren E, Hen R)

The young and the restless: regulation of adult neurogenesis by Wnt signaling. Cell Stem Cell. 12(2):139-40. 2013. (Wu MV, Hen R)

Adult neurogenesis modifies excitability of the dentate gyrus. Front Neural Circuits. 7:204. 2013. (Ikrar T, Guo N, He K, Besnard A, Levinson S, Hill A, Lee HK, Hen R, Xu X, Sahay A.)

Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality. Neuroscience, 248:436-447. 2013. (Perez-Sepulveda, J.A., Flagel, S.B., Garcia-Fuster, M.J., Slusky, R.J., Aldridge, J.W., Watson, S. & Akil, H.)

Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology, 76:425-436. 2013. (Flagel, S.B., Waselus, M., Clinton, S.M., Watson, S.J. & Akil, H.)

Theta oscillations in the medial prefrontal cortex are modulated by spatial working memory and synchronize with the hippocampus through its ventral subregion. J. Neuroscience, 33:14211-14224. 2013. (O’Neill, P.-K., J.A. Gordon, and T. Sigurdssson)

Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science, 340:1234-1239. 2013. (Ahmari, S.E., T. Spellman, N.L. Douglass, M.A. Kheirbeck, K. Deisseroth, J.A. Gordon, and R. Hen)

Inhibition of medio-dorsal thalamus disrupts thalamo-frontal connectivity and cognition. Neuron, 77:1151-1162. 2013. (Parnaudeau, S., P.K. O’Neill, S. Bolkan, R.D. Ward, A.I. Abbas, B.L. Roth, P. Balsam, J.A. Gordon, and C. Kellendonk)

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 2013 Mar 6;77(5):955-68. (Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R.)


Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling. Hippocampus 22:82–91. 2012. (Eiland, L. & McEwen, B.S.)

Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats.Psychoneuroendocrinology 37(1):39-47. 2012.(Eiland, L., Hill, M.N., Manley, J., McEwen, B.S., & Ramroop, J.)

A rat model of pre-puberty (Juvenile) stress-induced predisposition to stress-related disorders: Sex similarities and sex differences in effects and symptoms. World J Biol Psychiatry. 15(4):416-24. 2012. (Horovitz, O., Tsoory, M.M., Yovell, Y., & Richter-Levin, G)

Short- and long-term effects of juvenile stressor exposure on the expression of GABAA receptor subunits in rats. Stress. 15(4):416-24. 2012. (Jacobson-Pick, S., & Richter-Levin, G.)

Stimulus intensity-dependent modulations of hippocampal long-term potentiation by basolateral amygdala priming. Front Cell Neurosci. 6:21. 2012. (Li, Z., & Richter-Levin, G.)

Selective increase in the association of the β2 adrenergic receptor, β Arrestin-1 and p53 with Mdm2 in the ventral hippocampus one month after underwater trauma. Behav Brain Res 240C:26-28. 2012. (Sood, R., Ritov, G., Richter-Levin, G., &  Barki-Harrington, L.)

Chronic Intermittent Alcohol Vapor and Pulsatile Heroin Delivery Produce Dependence as Measured by Somatic and Negative Affective Indices during Spontaneous Withdrawal in Rats. Psychopharmacology. 223(1):75-88. 2012. (Powell, A.S., Reis, D.J., Walker, B.M., & Williams, A.M.)

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci. 2012 Dec;15(12):1613-20. Review. (Kheirbek MA, Klemenhagen KC, Sahay A, Hen R.)


From models to mechanisms: Odorant communication as a key determinant of social behavior during sickness-associated states. Neuroscience & Biobehavioral Reviews, 35: 1916-1928. 2011. (Arakawa, H., Cruz, S. & Deak, T.)

Stress-dependent changes in neuroinflammatory markers observed after common laboratory stressors are not seen following acute social defeat of the Sprague Dawley rat. Physiology & Behavior, 104: 187-198. 2011.  (Barnum, C.J., Buck, H.M., Deak, T., Eberle, J.A., Ferraioli, F.J., & Hueston, C.M.)

The extended granin family: structure, function and biomedical implications. Endocr. Rev., 32(6): 755-97. 2011. (Bartolomucci, A., Fischer-Colbrie, R., Mahata, S., Possenti, R., Loh, Y.P., & Salton, S.R.J.)

Acute effects of steroid hormones and neuropeptides on human social – emotional behavior: A review of single administration studies. Frontiers in Neuroendocrinology, 33: 17-35. 2011. (Bluthé, R.M., Bos, P., Honk, J., & Panksepp, J.)

Testosterone decreases trust in socially naïve humans. Proc Natl. Acad. Sci. 107. 0911700107. 2011. (Bos, P., Terburg, D. & van Honk, J.)

A silent synapse-based mechanism for cocaine-induced locomotor sensitization. Journal of Neuroscience, 31: 8163-8174. 2011. (Brown, T.E., Dong, Y., Huang ,Y.H., Lee, B.R., Mu, P., Nestler, E.J.,  Schlüter, O.M., Sorg, B.A., & Zukin, R.S.)

Positive effective vocalizations during cocaine and sucrose self-administration: A model for spontaneous drug desire in rats. Neuropharmacology. 61(1-2):268-75.  2011. (Browning, J.R., Browning, D.A., Maxwell, A.O., Dong, Y., Jansen, H.T., Panksepp, J., & Sorg, B.A.)

Selective p38a MAPK deletion in serotonergic neurons produces stress-resilience in models of depression and addiction. Neuron, 71: 498-511. 2011. (Bruchas, M.R., Chavkin, C ., Hagen, C., Land, B.B., Lemos, J.C., Messinger, D.I., Miyatake, M., Neumaier, J.N., Palmiter, R.D., Quintana, A., Schindler, A.G.,& Shankar, H.)

Motor and locomotor responses to systemic amphetamine in three lines of selectively bred Long-Evans rats. Pharmacology, Biochemistry and Behavior, 100: 119-124. 2011.(Brudzynski, S.M., Burgdorf J., Gibson, B., Kroes R.A., Moskal J.R., Panksepp, J., & Silkstone, M.)

A novel NMDA receptor glycine-site partial agonist, GLYX-13, could have therapeutic potential for the treatment of autism. Neuroscience & Biobehavioral Reviews, 35: 1982-1988. 2011. (Brudzynski, S.M., Burgdorf, J., Kroes, R.A., Moskal J.R., & Panksepp, J.)

Effects of intraacumbens amphetamine on production of 50 kHz vocalizations in three lines of selectively bred Long-Evans rats. Behavioural Brain Research, 217(1):32-40. 2011. (Brudzynski, S.M., Silkstone, M., Komadoski, M., Scullion, S., Duffus, S., Burgdorf, J., Kroes, R.A., Moskal, J.R. & Panksepp, J.)

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. Neuroscience. 192, 515-23. 2011. (Burgdorf, J., Kroes, R.A., Weiss, C., Oh, M.M., Disterhoft, J.F., Brudzynski, S.M., Panksepp, J., & Moskal, J.R.)

Panic as an Independent Risk Factor for Suicide Attempt in Depressive Illness: Findings from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry, 72: 1628-1635. 2011. (Cohen, L.J., Katz, C., Galynker, I.I. , . Mojtabai, R., & Yaseen, Z.S.)

A Useful Animal Model for Social-Affective Neuroscience Research: Basic description of separation distress, social attachments and play. Neuroscience and Biobehavioral Reviews, 35: 1854-63.  2011. (Colonnello, V., Fuchs, T., Iacobucci, P., Newberry, R.C., & Panksepp, J.)

Brief periods of positive peer interactions mitigate the effects of total social isolation in young Octodon degus. Dev Psychobiol. 53(3):280-90. 2011. (Colonnello, V., Iacobucci, P., Anderson, M.P. & Panksepp, J.)

Analysis of the disruption of maternal social bonds in Octodon degus: Separation distress in restricted reunion tests. Dev Psychobiol, 53: 657-669. 2011. (Colonnello, V., Iacobucci, P. & Panksepp, J.)

Rat pup social motivation: A critical component of early psychological development. Neurosci. BioBehavioral Reviews, 35: 1284–1290.  2011. (Cromwell H.C.)

Cocaine-induced metaplasticity in Nucleus Accumbens: Silent synapse and beyond. Neuropharmacology, 61: 1060-1069. 2011. (Dong, Y.  & Lee, B.R.)

Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling. Hippocampus, 22:82–91. 2012. (Eiland, L., & McEwen, B.S.) 

Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats. Psychoneuroendocrinology, 37:39-47. 2012. (Eiland, L., Ramroop, J., Hill, M.N., Manley, J., & McEwen, B.S.)

Effect of triiodothyronine on antidepressant screening tests in mice and on presynaptic 5-HT1a receptors: Mediation by thyroid hormone alpha receptors. Journal of Pharmacology and Experimental Therapeutics, 337: 494-502. 2011. (Eitan, R., Landshut, G., Lifschytz, T., Lerer, B., Ohayon, S. &. Zozulinsky, P.)

Remembering relationships: Preserved emotion-based learning in Alzheimer’s disease. Experimental Aging Research, 37(1): 1-16. 2011. (Evans-Roberts, C.E.Y. & Turnbull, O.H.)

Transient Neuronal Silencing Reveals Opposing Actions of Indirect and Direct Pathway Neurons on Amphetamine Sensitization. Nature Neuroscience. 14(1):22-4. 2011. (Ferguson, S.M., Eskenazi, D., Ishikawa, M., Wanat, M.J., Phillips, P.E.M., Dong, Y., Roth, B.L., & Neumaier, J.F.)

The ‘resting-state hypothesis’ of major depressive disorder—A translational subcortical–cortical framework for a system disorderNeuroscience and Biobehavioral Reviews, 35: 1929-1945. 2011. (Feinberg, T., Northoff, G., Panksepp, J., & Wiebking, C.)

Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: Relevance of animal affective systems to human disorders, with a focus on resilience to adverse events. Neuroscience & Biobehavioral Reviews , 35: 1876-188994. 2011. (Harro, J., Kanarik, M., Matrov,D., & Panksepp, J.)

Droplets of black bile? Development of vulnerability and resilience to depression in young age. Psychoneuroendocrinology, 36: 380-392. 2011. (Harro, J. & Kiive, E)

Searching for Presynaptic NMDA receptors in the Nucleus Accumbens. Revision in Journal of Neuroscience. 31(50): 18453-18463. 2011. (Huang, Y.H., Ishilawa, M., Lee, B.R., Schlüter, O.M., & Dong, Y.)

Cocaine-induced Homeostatic Regulation of Dysregulation of Nucleus Accumbens Neurons. Invited Review. Behavioral Brain Research. 216(1): 9-18. 2011. (Huang, Y.H., Schlüter, O.M., & Dong, Y.)

Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene epression in susceptible and resilient rats. European Neuropsychopharmacology, 21: 92-107. 2011. (Kanarik, M., Alttoa, A., Matrov, D., Kõiv, K., Sharp, T., Panksepp, J. & Harro, J.)

Disruption of circadian clocks has ramifications for metabolism, brain and behaviorPNAS 108(4):1657-62. 2011. (Karatsoreos, I.N., Bhagat, S.M., Bloss, E.B., Morrison, J.H. & McEwen, B.S.)

Exposure to Cocaine Alters Dynorphin-mediated Regulation of Excitatory Synaptic Transmission in Nucleus Accumbens Neurons. Biological Psychiatry, 69: 228-235. 2011. (Mu, P., Panksepp, J., Schlüter, O.M., Dong, Y.)

The basic neuroscience of emotional experiences in mammals: The case of subcortical FEAR circuitry and implications for clinical anxiety. Applied Animal Behaviour Sciences. 129, 1-17. 2011. (Panksepp, J., Fuchs, T. & Iacobucci, P.)

Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: Why depression feels so bad and what addicts really want. Neuroscience and Biobehavioral Reviews, 35: 2000-2008. 2011. (Panksepp, J., Solms, M., Watt, D.F., & Zellner, M.R.)

Why does depression hurt? Ancestral primary-process separation-distress (PANIC) and diminished brain reward (SEEKING) processes in the genesis of depressive affect. Psychiatry, 74, 5-14. 2011. (Panksepp, J., & Watt, J.)

Deconstructing Pediatric Major Depression Trials: An Analysis of the Effects of Patient Expectancy and Therapeutic Contact. J Am Acad Child Adolesc Psychiatry. 50(8):782-795. 2011. (Rutherford, B.R., Sneed, J.R., Tandler, J.M., Peterson, B.S., & Roose, S.P.)

Eye Tracking Unconscious Face-to-Face Confrontations: Dominance Motives Prolong Gaze to Masked Angry FacesPsychological Science 22(3) 314–319. 2011. (Terburg, D., Hooiveld, N., Aarts, H., Leon Kenemans, J, & van Honk, J.)

Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratioProc Natl. Acad. Sci. 108. (van Honk, J., Schutter, D.J., Bos, P.A.,  Wil Kruijtc, A., Lentjes, E.G. & Baron-Cohen, S.) 2011.

Toward affective circuit-based preclinical models of depression: Sensitizing dorsal PAG arousal leads to sustained suppression of positive affect in rats. Neurosci Biobehav Rev. 35(9) 1902-1915. 2011. (Wright, J.S., & Panksepp, J.)


Oxytocin and vasopressin in the medial amygdala differentially modulate approach and avoidance behavior toward illness-related social odor. Neuroscience, 171(4):1141-1151. 2010. (Arakawa, H., Arakawa, K. & Deak, T.)

Sickness-related odor communication signals as determinants of social behavior in rat: a role for inflammatory processes. Hormones & Behavior, 57(3), 330-341. 2010. (Arakawa, H., Arakawa, K. & Deak, T.)

Abnormal body perception and neural activity in the insula in depression: An fMRI study of the depressed “material me”. The World Journal of Biological Psychiatry, 11: 538-549. 2010. (Bauer, A., Duncan, N., de Greck, M., Northoff, G., Tempelmann, C., & Wiebking, C.)

Reducing hippocampal cell proliferation in the adult rat does not prevent the acquisition of cocaine-induced conditioned place preference. Neuroscience Letters. 481 (1): 41-46.  2010.(Brown, T.E., Lee, B.R., Ryu, V., Herzog, T., Czaja, K. & Dong Y.)

Uncovering the molecular basis of positive affect using rough-and- tumble play in rats: a role for insulin like growth factor. Neuroscience, 168, 769-77. 2010. (Burgdorf, J., Kroes, R.A., Beinfeld, M.C., Panksepp, J., &  Moskal, J.R.)

Vocal and locomotor responses of piglets to social isolation and reunion. Dev Psychobiol.;52(1):1-12. 2010. (Colonnello, V., Iacobucci, P., & Newberry, R.C.)

Emotion-based learning on the contingency-shifting variant Iowa Gambling Task. Journal of Clinical and Experimental Neuropsychology, 32(3): 239-248. 2010. (Dymond, S., Cella, M, Cooper, A. & Turnbull, O.H.)

The neuroanatomy of asomatognosia and somatoparaphrenia.J Neurol Neurosurg Psychiatry. 81: 276-281. 2010. (Feinberg, T., Venneri, A., Simone, A., Fan, Y. & Northoff, G.)

Infant-mother recognition in a social rodent (Octodon degus). Journal of Comparative Psychology; 124(2):166-75. 2010. (Fuchs, T, Iacobucci, P, MacKinnon, K.M & Panksepp, J)

Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology. Pharmacology & Therapeutics, 125: 402-422. 2010. (Harro, J.)

An Activity-Induced MicroRNA Controls Dendritic Spine Formation by Regulating Rac1-Pak signaling. Molecular and Cellular Neuroscience (43) 146-156. 2010. (Impey S.,  Davare M.,   Lesiak A., Fortin D., Ando H,  Varlamova O.,  Obrietan K., Soderling TR., Goodman RH, & Wayman G A.)

Differential impact of juvenile stress and corticosterone in juvenility and in adulthood, in male and female rats. Behav Brain Res. 214(2):268-76. 2010. (Jacobson-Pick, S. & Richter-Levin, G.)

Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats. Toxicol Lett. 199(2):136‐43. 2010. (Jolous‐Jamshidi, B, Cromwell, H.C, McFarland, A.M & Meserve, L.A)

Endocrine and physiological changes in response to chronic corticosterone: A potential model of the metabolic syndrome in mouse. Endocrinology, 151: 2117-2127. 2010. (Karatsoreos, I.N., Bhagat, S., Bowles, N.P., Weil, Z.M., Pfaff, D.W. & McEwen, B.S.)

Exposure to Cocaine Dynamically Regulates the Intrinsic Membrane Excitability of Nucleus Accumbens Neurons. Journal of Neuroscience, 20: 3689-3699. 2010. (Mu, P., Moyer, J.T., Panksepp, J., Sorg, B.A., Schlüter, O.M. & Dong, Y.)

Affective neuroscience of the emotional BrainMind: evolutionary perspectives and implications for understanding depression. Dialogues in Clinical Neuroscience, 12, 533-545. 2010. (Panksepp, J.).

Anxiety, depression and emotional profile in renal transplant recipients and healthy subjects: A comparative study. Transplantation Proceedings, 42(9), 3586-3590. 2010. (Pascazio, L., Nardone, I., Clarici, A., Enzmann, G., Grignetti, M., Panzetta, G. O., et al.)

Inverse effects of oxytocin on attributing mental activity to others in depressed and healthy subjects: a double-blind placebo controlled fMRI study. Frontiers in Psychiatry, 1, a134.  2010. (Pincus, D., Kose, S., Arana, A., Johnson, K., Morgan, P.S., Borckardt, J., Herbsman, T., Hardaway, F., George, M.S., Panksepp, J., &  Nahas, Z.)

A Translational Bridge Between Mouse and Human Models of Learned Safety. Annals of Medicine 42: 127-134. 2010. (Pollak, D., Rogan, M., Egner, T., Perez, D., Yanagihara, T. & J. Hirsh)

Anterior cingulate activity and the self in disorders of consciousness.Human Brain Mapping, (12):1993-2002. 2010. (Qin, P., Di, H., Lui, Y., Yu, S., Gong, Q., Duncan, N., Weng, X., Laureys, S., & Northoff, G.)

Antidepressant Study Design Affects Patient Expectations: Initial Results from a Randomized Controlled Trial. Psychological Medicine 2010; 40:781-788. 2010. (Rutherford, B.R., Sneed,  J.R., Eisenstadt, R., & Roose, S.P.)

In self-defense: Disruptions in the sense of self, lateralization and primitive defences. Neuropsychoanalysis, 12(2): 172-182. 2010. (Salas, C. E. & Turnbull, O.H.)

Knowing that you Care: Effects of perceived empathy and attachment style on pain. Pain, 151, 687–693. 2010. (Sambo, C., Howard, M., Williams, S., Kopelman, M. & Fotopoulou, A.)

Behavioral stress exposure may increase the rewarding valence of cocaine-associated cues through a dynorphin/kappa-opioid receptor-mediated mechanism without affecting associative learning or memory retrieval mechanisms. Neuropsychopharmacology, 35: 1932-1942. 2010. (Schindler, A. G., Li, S., & Chavkin, C.).

Regulation of the Postsynaptic Cytoskeleton: Roles in Development, Plasticity and Disorders. J. Neuroscience (30) 14937-42. 2010. (Svotloma, T., Lin, W.H., Webb, D. J., Yasuda, R., Wayman, G. A., Van Aelst, L.  & Soderling, S. H.)

“Juvenile stress” alters maturation-related changes in expression of the neural cell adhesion molecule L1 in the limbic system: relevance for stress-related psychopathologies. J Neurosci Res., 88(2):369-80. 2010. (Tsoory, M.M., Guterman, A. & Richter-Levin, G.)

Construct development: The Suicide Trigger Scale (STS-2), a measure of a hypothesized suicide trigger state. BMC Psychiatry. 10:110. 2010. (Yaseen, Z., Katz, C., Johnson, M.S., Eisenberg, D., Cohen, L.J. & Galynker II)


Central infusion of Interleukin-1 receptor antagonist blocked the reduction in social investigation produced by prior stressor exposurePhysiology & Behavior, 98, 139-146. 2009. (Arakawa, H., Blandino, Jr., P. & Deak, T.)

To lose the frame of action: A selective deficit in avoiding unpleasant objects following unilateral temporal lobe lesion. Neurocase, 15: 261-270. 2009. (Bamford, S., Turnbull, O.H., Coetzer, R. & Ward, R.)

Attentional modulation of emotional stimulus processing in patients with major depression—Alterations in prefrontal cortical regions.Neuroscience Letters Oct 2;463(2):108-13. 2009. (Bermpohl, F., Walter, M., Sajonz, B., Lücke, C., Hägele, C., Sterzer, P., Adli, M., Heinz, A., Northoff, G.)

Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stressBrain, Behavior & Immunity, 23, 958-968. 2009. (Blandino Jr., P, Barnum, C.J., Solomon, L.G., Larish, Y., Lankow, B.S. & Deak, T.)

Thyroid disorders in mental patients. Current Opinion in Psychiatry. 22, no. 4, p.391-395. 2009. (Bunevicius, R.)

Thyroid disease and mental disorders: cause and effect or only co-morbidity? Current Opinion in Psychiatry. 23: 363-368. 2009. (Bunevicius, R. & Prange, A.J.)

The effects of selective breeding for differential rates of 50-kHz ultrasonic vocalizations on emotional behavior in rats. Developmental Psychobiology, 51(1): 34-46. 2009. (Burgdorf, J, Panksepp, J, Brudzynski, S. M, Beinfeld, M. C, Cromwell, H. C, Kroes, R. A, & Moskal, J. R)

Stress-induced, glucocorticoid-dependent strengthening of glutamatergic synaptic transmission in midbrain dopamine neurons. Neuroscience Letters, 452 (3): 273-6. 2009. (Daftary S.S., Panksepp J., Dong Y. & Saal, D.B.)

Validation of a novel social investigation task that may dissociate social motivation from exploratory activity. Behavioural Brain Research, 199, 326-333. 2009. (Deak, T., Arakawa, H., Bekkedal, M.Y.V. & Panksepp, J.)

Is Our Self Nothing but Reward? Neuronal Overlap and Distinction between Reward and Personal Relevance and Its Relation to Human PersonalityPLoS ONE, Volume 4, Issue 12. 2009. (Enzi, B., de Greck, M.,  Prösch, U., Tempelmann, C. & Northoff, G.)

Neural mechanisms of grief regulationBiological Psychiatry, vol. 66 (1), 33-40. 2009.  (Freed, P.J., Yanagihara, T.K., Hirsch, J., & Mann, J. J.)

Altered Negative BOLD Responses in the Default-Mode Network during Emotion Processing in Depressed SubjectsNeuropsychopharmacology.;34(4):932-843. 2009. (Grimm, S., Boesiger, P.,  Beck, J., Schuepbach, D., Bermpohl, F., Walter, M., Ernst, J., Hell, D., Boeker, H. & Northoff, G.)

Increased Self-Focus in Major Depressive Disorder Is Related to Neural Abnormalities in Subcortical-Cortical Midline StructuresHuman Brain Mapping;30(8):2617-27. 2009. (Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H. & Northoff, G.)

Understanding the self: a cultural neuroscience approach. Progress in Brain Research, Vol. 178, ISSN 0079-6123. 2009. (Han, S., & Northoff, G.)

The effects of prenatal stress on social motivation in rat pup. Stress; 12(3):250‐8. 2009. (Harmon, K.M., McFarland, A.M., Beckwith, T.J., Greenwald, M. & Cromwell , H.C)

In vivo Cocaine Experience Generates Silent SynapsesNeuron, 63:40-47. 2009. (Huang, Y.H., Lin ,Y., Mu, P., Lee, B.R., Brown, T.E., Wayman, G.A., Marie, H., Liu, W., Yan, Z., Sorg, B.A., Schlüter, O.M., Zukin, R.S. & Dong, Y.)

Enriched Environment Experience Overcomes Learning Deficits and Depressive-Like Behavior induced by Juvenile Stress. PLoS One. 4(1). 2009. (Ilin, Y., Richter-Levin, G.)

ERK2 and CREB activation in the amygdala when an event is remembered as “Fearful” and not when it is remembered as “Instructive”. J Neurosci Res. Jun;87(8):1823-31. 2009. (Ilin Y, Richter-Levin G.)

Homeostatic Synapse-driven Membrane Plasticity in Nucleus Accumbens NeuronsJournal of Neuroscience, 29 (18): 5820-31. 2009. (Ishikawa, M., Moyer, J., Wolf, J.A., Quock, R.M., Davis, N.M., Hu, X.T., Schlüter, O.M. & Dong, Y.)

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proceedings of the National Academy of Sciences of the USA, 106: 19168-19173. 2009. (Land, B. B., Bruchas, M. R., Schattauer, S., Giardino, W. J., Aita, M., Messinger, D., Hnasko, T. S., Palmiter, R. D., & Chavkin, C.)

Two different putative genetic animal models of childhood depression – A review. Progress in Neurobiology, 88, 153–169. 2009. (Malkesman, O. & Weller, A.)

Effect of chronic stress on behavior and cerebral oxidative metabolism in rats with high or low positive affect. Neuroscience, 164: 963-974. 2009. (Mällo, T., Matrov, D., Kõiv, K. & Harro, J)

Wistar‐Kyoto rats as an animal model of anxiety vulnerability: Support for a hyper‐vigilance hypothesis. Behav Brain Res. 204(1):162‐8. 2009. (McAuley, J.D., Stewart, A.L., Webber, E.S., Cromwell, H.C., Servatius, R.J. & Pang, K.C.H.)

Repeated Cocaine Exposure Induces Sensitization of Ultrasonic Vocalization in Rats. Neuroscience Letter, 453 (1): 31-5. 2009. (Mu, P., Fuchs, T., Saal, D.B., Sorg, B., Dong, Y. & Panksepp, J.).

The trans-species core SELF: The emergence of active cultural and neuro-ecological agents through self-related processing within subcortical-cortical midline networksConsciousness and Cognition 2009 Mar;18(1):193-215. 2009. (Panksepp, J., & Northoff, G.)

From high anxiety trait to depression: a neurocognitive hypothesis. Trends Neurosci. 32(6):312-20. 2009. (Sandi, C. & Richter-Levin, G.)

The Relationship Between Aberrant Neuronal Activation in the Pregenual Anterior Cingulate, Altered Glutamatergic Metabolism, and Anhedonia in Major Depression. Archives of General Psychiatry, 66(5): 478-486. 2009. (Walter, M., Henning, A., Grimm, S., Schulte R.F., Beck, J., Dydak, U., Schnepf, B., Boeker, H., Boesiger, P. & Northoff, G.)


Social status modulates basal IL-1 concentrations in the hypothalamus of pair-housed rats and influences certain features of stress reactivity. Brain, Behavior & Immunity, 22, 517-527. 2008. (Barnum, C. J., Blandino Jr., P., & Deak, T.)

Rats selectively bred for low levels of 50 kHz ultrasonic vocalizations exhibit alterations in early social motivation. Developmental Psychobiology, 50(4): 322-331. 2008. (Brudzynski, S. M, Burgdorf, J., Cromwell, H. C, Harmon, K. M, Kroes, R. A, Moskal, J. R, & Panksepp, J.)

Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: Behavioral concomitants, relationship to reward, and self-administration of playback. Journal of Comparative Psychology,122(4):357-67. 2008. (Burgdorf, J., Kroes, R.A., Moskal, J.R., Pfaus, JG., Brudzynski, S.M., & Panksepp, J.)

Immune cells and cytokine circuits: Toward a working model for understanding direct immune-to-adrenal communication pathways. Endocrinology, 149(4), 1433-1435. 2008. (Deak, T.)

Increased serotonin 2C receptor mRNA editing: A possible risk factor for suicide, Mol Psychiatry 13, 1001-1010. 2008. (Dracheva, S., Patel, N., Woo, D.A., Marcus, S.M., Siever, L.J., & Haroutunian, V.)

Culture-sensitive neural substrates of human cognition: a transcultural neuroimaging approach. Nature Reviews: Neuroscience, 9(8): 646-654. 2008. (Han, S., & Northoff, G.)

Rats selectively bred for low levels of 50 kHz ultrasonic vocalizations exhibit alterations in early social motivationDevelopmental Psychobiology, 50 (4):  322-331. 2008. (Harmon, K. M, Cromwell, H.C, Burgdorf, J., Moskal, J.R, Brudzynski, S. M., Kroes, R. A, & Panksepp, J.)

CREB modulates the functional output of nucleus accumbens neurons: A critical role of N-methyl-D-aspartate glutamate receptor (NMDAR) receptors. The Journal of Biological Chemistry, 283(5): 2751-2760. 2008. (Huang, Y. H., Lin, Y., Brown, T. E., Han, M-H., Saal, D. B., Neve, R. L., Zukin, R. S., Sorg, B. A., Nestler, E. J., Malenka, R. C., & Dong, Y.)

The dysphoric component of stress is encoded by activation of the dynorphin-kappa opioid system. Journal of Neuroscience 28(2):407-414. 2008. (Land, B.B., Bruchas, M.R., Melief, E., Xu, M., Lemos, J.C., and Chavkin, C.)

Homeostatic recovery of downstate-upstate cycling in nucleus accumbens neurons. Neuroscience Letters, 434: 282-288. 2008. (Lee, B. R., Mu, P., Saal, D. B., Ulibarri, C., & Dong, Y.)

The trans-species concept of self and the subcortical–cortical midline systemTrends in Cognitive Sciences 2008, (Northoff, G., Panksepp, J.)

An Animal Model of a Behavioral Intervention for Depression. Neuron 60: 149-161. 2008.(Pollak, D., Monje,F., Zuckerman L., Denny, C., Drew, M.,  Kandel,  E.R.)

The resting brain and our Self: Self-relatedness modulates resting state neural activity in cortical midline structuresNeuroscience 2008 Nov 11; 157(1):120-31. 2008. (Schneider, F., Bermpohl, F., Heinzel, A., Rotte, M., Walter, M., Tempelmann, C., Wiebking, C., Dobrowolny, H.,  Jochen Heinze, H., Northoff, G.)

GABA(B) receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of ratsBrain Research, 1191: 63-8. 2008. (Tyszkiewicz, J.P., Fong, T.M., Dong, Y.)


Adaptation of corticosterone and hyperthermic responses to stress following repeated stressor exposure. Journal of Neuroendocrinology, 19(8): 632-642. 2007. (Barnum, C. J., Blandino Jr., P., & Deak, T.).

From hippocampus to dorsal horn: the pervasive impact of IL-1 on learning and memory spans the length of the neuroaxis. Brain, Behavior & Immunity, 21: 746-747. 2007. (Deak, T)

Tickling-induced 50-kHz ultrasonic vocalization is individually stable and predicts behaviour in tests of anxiety and depression in rats. Behavioural Brain Research, 184: 57-71. 2007. (Mällo, T., Matrov D., Herm, L., Kõiv, K., Eller M., Rinken A., & Harro, J.)

Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science, 318: 980-985. 2007. (Manganas, L. N., Zhang, X., Li, Y., Hazel, R. D, Smith, S. D, Wagshul, M. E, Henn, F., Benveniste, H., Djuric, P. M, Enikolopov, G., & Maletic-Savatic, M.)

GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nature Neuroscience, 10(12): 1515-1517. 2007. (Northoff, G., Walter, M., Schulte, R.F., Beck, J., Dydak, U., Henning, A., Boeker, H., Grimm, S., & Boesiger, P.)

Brain regional neuropeptides changes resulting from social defeat. Behavioral Neuroscience, 121(6): 1364-1371. 2007. (Panksepp, J., Burgdorf, J., Beinfeld, M. C., Kroes, R. A., & Moskal, J. R.)