2011 HDRF funded Research Publications

From models to mechanisms: Odorant communication as a key determinant of social behavior during sickness-associated states. Neuroscience & Biobehavioral Reviews, 35: 1916-1928. 2011. (Arakawa, H., Cruz, S. & Deak, T.)

Stress-dependent changes in neuroinflammatory markers observed after common laboratory stressors are not seen following acute social defeat of the Sprague Dawley rat. Physiology & Behavior, 104: 187-198. 2011.  (Barnum, C.J., Buck, H.M., Deak, T., Eberle, J.A., Ferraioli, F.J., & Hueston, C.M.)

Acute effects of steroid hormones and neuropeptides on human social – emotional behavior: A review of single administration studies. Frontiers in Neuroendocrinology, 33: 17-35. 2011. (Bluthé, R.M., Bos, P., Honk, J., & Panksepp, J.)

Testosterone decreases trust in socially naïve humans. Proc Natl. Acad. Sci. 107. 0911700107. 2011. (Bos, P., Terburg, D. & van Honk, J.)

A silent synapse-based mechanism for cocaine-induced locomotor sensitization. Journal of Neuroscience, 31: 8163-8174. 2011. (Brown, T.E., Dong, Y., Huang ,Y.H., Lee, B.R., Mu, P., Nestler, E.J.,  Schlüter, O.M., Sorg, B.A., & Zukin, R.S.)

Positive effective vocalizations during cocaine and sucrose self-administration: A model for spontaneous drug desire in rats. Neuropharmacology. 61(1-2):268-75.  2011. (Browning, J.R., Browning, D.A., Maxwell, A.O., Dong, Y., Jansen, H.T., Panksepp, J., & Sorg, B.A.)

Selective p38a MAPK deletion in serotonergic neurons produces stress-resilience in models of depression and addiction. Neuron, 71: 498-511. 2011. (Bruchas, M.R., Chavkin, C ., Hagen, C., Land, B.B., Lemos, J.C., Messinger, D.I., Miyatake, M., Neumaier, J.N., Palmiter, R.D., Quintana, A., Schindler, A.G.,& Shankar, H.)

Motor and locomotor responses to systemic amphetamine in three lines of selectively bred Long-Evans rats. Pharmacology, Biochemistry and Behavior, 100: 119-124. 2011.(Brudzynski, S.M., Burgdorf J., Gibson, B., Kroes R.A., Moskal J.R., Panksepp, J., & Silkstone, M.)

<A novel NMDA receptor glycine-site partial agonist, GLYX-13, could have therapeutic potential for the treatment of autism. Neuroscience & Biobehavioral Reviews, 35: 1982-1988. 2011. (Brudzynski, S.M., Burgdorf, J., Kroes, R.A., Moskal J.R., & Panksepp, J.)

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. Neuroscience. 192, 515-23. 2011. (Burgdorf, J., Kroes, R.A., Weiss, C., Oh, M.M., Disterhoft, J.F., Brudzynski, S.M., Panksepp, J., & Moskal, J.R.)

Panic as an Independent Risk Factor for Suicide Attempt in Depressive Illness: Findings from the National Epidemiological Survey on Alcohol and Related Conditions (NESARC). J Clin Psychiatry, 72: 1628-1635. 2011. (Cohen, L.J., Katz, C., Galynker, I.I. , . Mojtabai, R., & Yaseen, Z.S.)

A Useful Animal Model for Social-Affective Neuroscience Research: Basic description of separation distress, social attachments and play. Neuroscience and Biobehavioral Reviews, 35: 1854-63.  2011. (Colonnello, V., Fuchs, T., Iacobucci, P., Newberry, R.C., & Panksepp, J.)

Brief periods of positive peer interactions mitigate the effects of total social isolation in young Octodon degus. Dev Psychobiol. 53(3):280-90. 2011. (Colonnello, V., Iacobucci, P., Anderson, M.P. & Panksepp, J.)

<Analysis of the disruption of maternal social bonds in Octodon degus: Separation distress in restricted reunion tests. Dev Psychobiol, 53: 657-669. 2011. (Colonnello, V., Iacobucci, P. & Panksepp, J.)

Rat pup social motivation: A critical component of early psychological development. Neurosci. BioBehavioral Reviews, 35: 1284–1290.  2011. (Cromwell H.C.)

<Cocaine-induced metaplasticity in Nucleus Accumbens: Silent synapse and beyond. Neuropharmacology, 61: 1060-1069. 2011. (Dong, Y.  & Lee, B.R.)

Early life stress followed by subsequent adult chronic stress potentiates anxiety and blunts hippocampal structural remodeling. Hippocampus, 22:82–91. 2012. (Eiland, L., & McEwen, B.S.) 

Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats. Psychoneuroendocrinology, 37:39-47. 2012. (Eiland, L., Ramroop, J., Hill, M.N., Manley, J., & McEwen, B.S.)

Effect of triiodothyronine on antidepressant screening tests in mice and on presynaptic 5-HT1a receptors: Mediation by thyroid hormone alpha receptors. Journal of Pharmacology and Experimental Therapeutics, 337: 494-502. 2011. (Eitan, R., Landshut, G., Lifschytz, T., Lerer, B., Ohayon, S. &. Zozulinsky, P.)

Remembering relationships: Preserved emotion-based learning in Alzheimer’s disease. Experimental Aging Research, 37(1): 1-16. 2011. (Evans-Roberts, C.E.Y. & Turnbull, O.H.)

Transient Neuronal Silencing Reveals Opposing Actions of Indirect and Direct Pathway Neurons on Amphetamine Sensitization. Nature Neuroscience. 14(1):22-4. 2011. (Ferguson, S.M., Eskenazi, D., Ishikawa, M., Wanat, M.J., Phillips, P.E.M., Dong, Y., Roth, B.L., & Neumaier, J.F.)

The ‘resting-state hypothesis’ of major depressive disorder—A translational subcortical–cortical framework for a system disorderNeuroscience and Biobehavioral Reviews, 35: 1929-1945. 2011. (Feinberg, T., Northoff, G., Panksepp, J., & Wiebking, C.)

Mapping patterns of depression-related brain regions with cytochrome oxidase histochemistry: Relevance of animal affective systems to human disorders, with a focus on resilience to adverse events. Neuroscience & Biobehavioral Reviews , 35: 1876-188994. 2011. (Harro, J., Kanarik, M., Matrov,D., & Panksepp, J.)

Droplets of black bile? Development of vulnerability and resilience to depression in young age. Psychoneuroendocrinology, 36: 380-392. 2011. (Harro, J. & Kiive, E)

Searching for Presynaptic NMDA receptors in the Nucleus Accumbens. Revision in Journal of Neuroscience. 31(50): 18453-18463. 2011. (Huang, Y.H., Ishilawa, M., Lee, B.R., Schlüter, O.M., & Dong, Y.)

Cocaine-induced Homeostatic Regulation of Dysregulation of Nucleus Accumbens Neurons. Invited Review. Behavioral Brain Research. 216(1): 9-18. 2011. (Huang, Y.H., Schlüter, O.M., & Dong, Y.)

Brain responses to chronic social defeat stress: effects on regional oxidative metabolism as a function of a hedonic trait, and gene epression in susceptible and resilient rats. European Neuropsychopharmacology, 21: 92-107. 2011. (Kanarik, M., Alttoa, A., Matrov, D., Kõiv, K., Sharp, T., Panksepp, J. & Harro, J.)

Disruption of circadian clocks has ramifications for metabolism, brain and behaviorPNAS 108(4):1657-62. 2011. (Karatsoreos, I.N., Bhagat, S.M., Bloss, E.B., Morrison, J.H. & McEwen, B.S.)

Exposure to Cocaine Alters Dynorphin-mediated Regulation of Excitatory Synaptic Transmission in Nucleus Accumbens Neurons. Biological Psychiatry, 69: 228-235. 2011. (Mu, P., Panksepp, J., Schlüter, O.M., Dong, Y.)

The basic neuroscience of emotional experiences in mammals: The case of subcortical FEAR circuitry and implications for clinical anxiety. Applied Animal Behaviour Sciences. 129, 1-17. 2011. (Panksepp, J., Fuchs, T. & Iacobucci, P.)

Affective neuroscientific and neuropsychoanalytic approaches to two intractable psychiatric problems: Why depression feels so bad and what addicts really want. Neuroscience and Biobehavioral Reviews, 35: 2000-2008. 2011. (Panksepp, J., Solms, M., Watt, D.F., & Zellner, M.R.)

Why does depression hurt? Ancestral primary-process separation-distress (PANIC) and diminished brain reward (SEEKING) processes in the genesis of depressive affect. Psychiatry, 74, 5-14. 2011. (Panksepp, J., & Watt, J.)

Deconstructing Pediatric Major Depression Trials: An Analysis of the Effects of Patient Expectancy and Therapeutic Contact. J Am Acad Child Adolesc Psychiatry. 50(8):782-795. 2011. (Rutherford, B.R., Sneed, J.R., Tandler, J.M., Peterson, B.S., & Roose, S.P.)

Eye Tracking Unconscious Face-to-Face Confrontations: Dominance Motives Prolong Gaze to Masked Angry FacesPsychological Science 22(3) 314–319. 2011. (Terburg, D., Hooiveld, N., Aarts, H., Leon Kenemans, J, & van Honk, J.)

Testosterone administration impairs cognitive empathy in women depending on second-to-fourth digit ratioProc Natl. Acad. Sci. 108. (van Honk, J., Schutter, D.J., Bos, P.A.,  Wil Kruijtc, A., Lentjes, E.G. & Baron-Cohen, S.) 2011.

Toward affective circuit-based preclinical models of depression: Sensitizing dorsal PAG arousal leads to sustained suppression of positive affect in rats. Neurosci Biobehav Rev. 35(9) 1902-1915. 2011. (Wright, J.S., & Panksepp, J.)