2013 HDRF funded Research Publications

Hippocampal gene expression changes underlying stress sensitization and recovery. Molecular Psychiatry. 2013. (Gray J.D., Rubin T.G., Hunter R.G. and McEwen B.S.)

Rapid Anxiolytic Effects of a 5-HT(4) Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism. Neuropsychopharmacology. 2013. (Mendez-David I., David D.J., Darcet F., Wu M.V., Kerdine-Römer S., Gardier A.M., Hen R.)

Developmental Effects of Serotonin 1A Autoreceptors on Anxiety and Social Behavior. Neuropsychopharmacology. 2013 Aug (Donaldson Z.R., Piel D.A., Santos T.L., Richardson-Jones J., Leonardo E.D., Beck S.G., Champagne F.A., Hen R.)

Add neurons, subtract anxiety. Scientific American (in press). 2013. (Kheirbek M.A., Hen R.)

Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn Mem. 2013. (Drew L.J., Fusi S., Hen R.)

Antidepressant and anxiolytic potential of the multimodal antidepressant vortioxetine (Lu AA21004) assessed by behavioural and neurogenesis outcomes in mice. Neuropharmacology. 2013. (Guilloux J.P., Mendez-David I., Pehrson A., Guiard B.P., Repérant C., Orvoën S., Gardier A.M., Hen R., Ebert B., Miller S., Sanchez C., David D.J.)

Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science. 2013. (Ahmari S.E., Spellman T., Douglass N.L., Kheirbek M.A., Simpson H.B., Deisseroth K., Gordon J.A., Hen R.)

(Radio)active neurogenesis in the human hippocampus. Cell. 2013. (Kheirbek M.A., Hen R.)

Genetic approaches for understanding the role of serotonin receptors in mood and behavior. Curr Opin Neurobiol. 2013. (Donaldson Z.R., Nautiyal K.M., Ahmari S.E., Hen R.).

Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology. 2013. (Boldrini M., Santiago A.N., Hen R., Dwork A.J., Rosoklija G.B., Tamir H., Arango V., John Mann J.)

Neuronal plasticity and antidepressant actions. Trends in Neuroscience. 2013. (Castren E., Hen R.)

The young and the restless: regulation of adult neurogenesis by Wnt signaling. Cell Stem Cell. 2013. (Wu M.V., Hen R.)

Adult neurogenesis modifies excitability of the dentate gyrus. Front Neural Circuits. 2013. (Ikrar T., Guo N., He K., Besnard A., Levinson S., Hill A., Lee H.K., Hen R., Xu X., Sahay A.)

Differential impact of a complex environment on positive affect in an animal model of individual differences in emotionality. Neuroscience. 2013. (Perez-Sepulveda, J.A., Flagel, S.B., Garcia-Fuster, M.J., Slusky, R.J., Aldridge, J.W., Watson, S. & Akil, H.)

Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology. 2013. (Flagel, S.B., Waselus, M., Clinton, S.M., Watson, S.J. & Akil, H.)

Theta oscillations in the medial prefrontal cortex are modulated by spatial working memory and synchronize with the hippocampus through its ventral subregion. J. Neuroscience. 2013. (O’Neill, P.K., Gordon J.A., and Sigurdssson T.)

Repeated cortico-striatal stimulation generates persistent OCD-like behavior. Science. 2013. (Ahmari, S.E., Spellman T., Douglass N.L., Kheirbeck M.A., Deisseroth K., Gordon J.A. and Hen R.)

Inhibition of medio-dorsal thalamus disrupts thalamo-frontal connectivity and cognition. Neuron. 2013. (Parnaudeau, S., O’Neill P.K., Bolkan S., Ward R.D., Abbas A.I., Roth B.L., Balsam P., Gordon J.A., and Kellendonk C.)

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 2013 Mar. (Kheirbek M.A., Drew L.J., Burghardt N.S., Costantini D.O., Tannenholz L., Ahmari S.E., Zeng H., Fenton A.A., Hen R.)