2020 HDRF Funded Research Publications

• Is depression a disorder of electrical brain networks? Neuropsychopharmacology. January 2020. (Grossman Y, Dzirasa K. )
• Rapid Anxiolytic Effects of RS67333, a Serotonin Type 4 Receptor Agonist, and Diazepam, a Benzodiazepine, Are Mediated by Projections From the Prefrontal Cortex to the Dorsal Raphe Nucleus. Biol Psychiatry. March 2020. (Faye C, Hen R, Guiard BP, Denny CA, Gardier AM, Mendez-David I, David DJ.)
• Classifying Depression Severity in Recovery From Major Depressive Disorder via Dynamic Facial Features. IEEE J Biomed Health Inform. March 2020. (Harati S, Crowell A, Huang Y, Mayberg H, Nemati S.)
• Concordance between clinician-rated and patient reported outcome measures of depressive symptoms in treatment resistant depression. J Affect Disord. April 2020. (Hershenberg R, McDonald WM, Crowell A, Riva-Posse P, Craighead WE, Mayberg HS, Dunlop BW.)
• Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight from a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model. Biol Psychiatry. May 2020. (Birt IA, Hagenauer MH, Clinton SM, Aydin C, Blandino P Jr, Stead JDH, Hilde KL, Meng F, Thompson RC, Khalil H, Stefanov A, Maras P, Zhou Z, Hebda-Bauer EK, Goldman D, Watson SJ Jr, Akil H.)
• Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression. Neuron. June 2020. (Issler O, van der Zee YY, Ramakrishnan A, Wang J, Tan C, Loh YE, Purushothaman I, Walker DM, Lorsch ZS, Hamilton PJ, Peña CJ, Flaherty E, Hartley BJ, Torres-Berrío A, Parise EM, Kronman H, Duffy JE, Estill MS, Calipari ES, Labonté B, Neve RL, Tamminga CA, Brennand KJ, Dong Y, Shen L, Nestler EJ.)
• Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models. Biological Psychiatry. July 2020. (Scarpa JR, Fatma M, Loh YE, Traore SR, Stefan T, Chen TH, Nestler EJ, Labonté B.)
• The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biol Psychiatry. July 2020. (Coleman JRI, Gaspar HA, Bryois J; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Breen G.)
• Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach. Annu Rev Neurosci. July 2020. (Emery MA, Akil H.)
• Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/4 homodimer selectivity. Bioorg Med Chem Lett. July 2020. (Fulton MG, Loch MT, Rodriguez AL, Lin X, Javitch JA, Conn PJ, Niswender CM, Lindsley CW.)
• Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation. Mol Psychiatry. September 2020. (Donthamsetti P, Gallo EF, Buck DC, Stahl EL, Zhu Y, Lane JR, Bohn LM, Neve KA, Kellendonk C, Javitch JA.
• Maternal antenatal depression and child mental health: Moderation by genomic risk for attention deficit/hyperactivity disorder. Dev Psychopathol. December 2020. (Chen LM, Tollenaar M, Dass SHH, Bouvette-Turcot A, Pokhvisneva I, Gaudreau H, Parent C, Diorio J, McEwen L, MacIsaac J, Kobor M, Beijers R, de Weerth C, Silveira P, Karama S, Meaney MJ, O’Donnell KJ.)
• Addressing the Credit Assignment Problem in Treatment Outcome Prediction using Temporal Difference Learning. Pac Symp Biocomput. 2020. (Harati S, Crowell A, Mayberg H, Nemati S.)