2021 HDRF Funded Research Publications

• Dissecting diagnostic heterogeneity in depression by integrating neuroimaging and genetics. Neuropsychopharmacology. January 2021. (Buch AM, Liston C.)
• A novel luminescence-based β-arrestin recruitment assay for unmodified receptors. J Biol Chem. January 2021. (Hauge Pedersen M, Pham J, Mancebo H, Inoue A, Asher WB, Javitch JA.)
• Combined effects of genotype and childhood adversity shape variability of DNA methylation across age. Transl Psychiatry. February 2021. (Czamara D, Tissink E, Tuhkanen J, Martins J, Awaloff Y, Drake AJ, Khulan B, Palotie A, Winter SM, Nemeroff CB, Craighead WE, Dunlop BW, Mayberg HS, Kinkead B, Mathew SJ, Iosifescu DV, Neylan TC, Heim CM, Lahti J, Eriksson JG, Räikkönen K, Ressler KJ, Provençal N, Binder EB.)
• Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression. Psychoneuroendocrinology. February 2021. (Eliwa H, Brizard B, Le Guisquet AM, Hen R, Belzung C, Surget A.)
• The future of personalized brain stimulation. Nat Med. February 2021. (Figee M, Mayberg H.)
• Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress. Mol Psychiatry. February 2021. (Föcking M, Sabherwal S, Cates HM, Scaife C, Dicker P, Hryniewiecka M, Wynne K, Rutten BPF, Lewis G, Cannon M, Nestler EJ, Heurich M, Cagney G, Zammit S, Cotter DR.)
• Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Mol Psychiatry. April 2021. (Andlauer TFM, et al. Bipolar Disorder Working Group of the Psychiatric Genomics Consortium); Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Rivas F, Mayoral F, Müller-Myhsok B, Forstner AJ, Nöthen MM, Rietschel M.)
• Single-molecule FRET imaging of GPCR dimers in living cells. Nat Methods. April 2021. (Asher WB, Geggier P, Holsey MD, Gilmore GT, Pati AK, Meszaros J, Terry DS, Mathiasen S, Kaliszewski MJ, McCauley MD, Govindaraju A, Zhou Z, Harikumar KG, Jaqaman K, Miller LJ, Smith AW, Blanchard SC, Javitch JA.)
• Accelerated brain aging predicts impulsivity and symptom severity in depression. Neuropsychopharmacology. April 2021. (Dunlop K, Victoria LW, Downar J, Gunning FM, Liston C.)
• Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy. Nat Commun. June 2021. (Bhowmik S, Galeta J, Havel V, Nelson M, Faouzi A, Bechand B, Ansonoff M, Fiala T, Hunkele A, KruegelAC, Pintar JE, Majumdar S, Javitch JA, Sames D.)
• Maternal adverse childhood experience and depression in relation with brain network development and behavior in children: a longitudinal study. Cerebral Cortex. July 2021. (Zhang H, Wong TY, Broekman BFP, Chong YS, Shek LP; Gluckman PD, Tan KH, Meaney MJ, Fortier MV, Qiu A.)
• Long-term precision editing of nearual circuits using engineered gap junction hemichannels. bioRxiv. August 2021. (Ransey E, Chesnov K, Wisdom E, Bowman R, Rodrigues T, Adamson E, Thomas GE, Almoril-Porras A, Schwennesen H, Colon-Ramos D, Hultman R, Bursac N, Dzirasa K.)
• A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. J Med Chem. September 2021. (Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, Filizola M, van Rijn RM, Margolis EB, Roth BL, McLaughlin JP, Che T, Sames D, Javitch JA, Majumdar S.)
• Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing. Sci Adv. October 2021. (Andrianarivelo A, Saint-Jour E, Pousinha P, Fernandez SP, Petitbon A, De Smedt-Peyrusse V, Heck N, Ortiz V, Allichon MC, Kappès V, Betuing S, Walle R, Zhu Y, Joséphine C, Bemelmans AP, Turecki G, Mechawar N, Javitch JA, Caboche J, Trifilieff P, Barik J, Vanhoutte P.)
• ANA Investigates: Neural Circuit Concepts Connecting Neurology and Psychiatry. Ann Neurol. October 2021. (Das RR, Goss AL, Richie M, Geocadin RG, Mayberg HS.)
• Directed Spectral Measures Improve Latent Network Models Of Neural Populations. Adv Neural Inf Process Syst. December 2021. (Gallagher NM, Dzirasa K, Carlson D.)