2022 HDRF Funded Research Publications

• Whole blood transcriptional signatures associated with rapid antidepressant response to ketamine in patients with treatment resistant depression. Transl Psychiatry. January 2022. (Cathomas F, Bevilacqua L, Ramakrishnan A, Kronman H, Costi S, Schneider M, Chan KL, Li L, Nestler EJ, Shen L, Charney DS, Russo SJ, Murrough JW.)
• Sex-Specific Transcriptional Changes in Response to Adolescent Social Stress in the Brain’s Reward Circuitry. Biological Psychiatry. January 2022. (Walker DM, Zhou X, Cunningham AM, Lipschultz AP, Ramakrishnan A, Cates HM, Bagot RC, Shen L, Zhang B, Nestler EJ.)
• Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biol Psychiatry. January 2022. (Blokland GAM; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, et al. )
• Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene. Transl Psychiatry. March 2022. (Caradonna SG, Einhorn NR, Saudagar V, Khalil H, Petty GH, Lihagen A, LeFloch C, Lee FS, Akil H, Guidotti A, McEwen BS, Gatta E, Marrocco J.)
• Differences in microglia morphological profiles reflect divergent emotional temperaments: insights from a selective breeding model. Transl Psychiatry. March 2022. (Maras PM, Hebda-Bauer EK, Hagenauer MH, Hilde KL, Blandino P Jr, Watson SJ Jr, Akil H.)
• Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. Mol Psychiatry. March 2022. (Gallo EF, Greenwald J, Yeisley J, Teboul E, Martyniuk KM, Villarin JM, Li Y, Javitch JA, Balsam PD, Kellendonk C. )
• Time for united action on depression: a Lancet-World Psychiatric Association Commission. Lancet. March 2022. (Herrman H, Patel V, Kieling C, Berk M, Buchweitz C, Cuijpers P, Furukawa TA, Kessler RC, Kohrt BA, Maj M, McGorry P, Reynolds CF 3rd, Weissman MM, Chibanda D, Dowrick C, Howard LM, Hoven CW, Knapp M, Mayberg HS, Penninx BWJH, Xiao S, Trivedi M, Uher R, Vijayakumar L, Wolpert M.)
• Beyond the neuron: Role of non-neuronal cells in stress disorders. Neuron. April 2022. (Cathomas F, Holt LM, Parise EM, Liu J, Murrough JW, Casaccia P, Nestler EJ, Russo SJ.)
• Brain charts for the human lifespan. Nature. April 2022. (Bethlehem RAI and the PREVENT AD Research group.)
• Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress. Neuropsychopharmacology. April 2022. (Caradonna SG, Zhang TY, O’Toole N, Shen M-J, Khalil H, Einhorn NR, Wen X, Parent C, Lee FS, Akil H, Meaney MJ, McEwen BS, Marrocco J.)
• GPCRmediated β-arrestin activation deconvoluted with single-molecule precision. Cell. May 2022. (Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, Lefkowitz RJ, Blanchard SC, Javitch JA.)
• Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study. Am J Psychiatry. May 2022. (Cruceanu C, Dony L, Krontira AC, Fischer DS, Roeh S, Di Giaimo R, Kyrousi C, Kaspar L, Arloth J, Czamara D, Gerstner N, Martinelli S, Wehner S, Breen MS, Koedel M, Sauer S, Sportelli V, Rex-Haffner M, Cappello S, Theis FJ, Binder EB.)
• Brain-wide electrical dynamics encode individual appetitive social behavior. Neuron. May 2022. (Mague SD, Talbot A, Blount C, Walder-Christensen KK, Duffney LJ, Adamson E, Bey AL, Ndubuizu N, Thomas GE, Hughes DN, Grossman Y, Hultman R, Sinha S, Fink AM, Gallagher NM, Fisher RL, Jiang YH, Carlson DE, Dzirasa K)
• Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children. Molecular Psychiatry. June 2022. (Restrepo-Lozano JM, Pokhvisneva I, Wang Z, Patel S, Meaney MJ, Silveira PP, Flores C.)
• Integrative PheWAS analysis in risk categorization of major depressive disorder and identifying their associations with genetic variants using a latent topic model approach. Transl Psychiatry. June 2022. (Meng X, Wang M, O’Donnell KJ, Caron J, Meaney MJ, Li Y.)
• Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine. Neuropsychopharmacology. June 2022. (Han J, Andreu V, Langreck C, Pekarskaya EA, Grinnell SG, Allain F, Magalong V, Pintar J, Kieffer BL, Harris AZ, Javitch JA, Hen R, Nautiyal KM.)
• Deep Brain Stimulation for Depression. Neurotherapeutics. July 2022. (Figee M, Riva-Posse P, Choi KS, Bederson L, Mayberg HS, Kopell BH.)
• Transcriptional Profiling of the Hippocampus in an F2 Cross of a Genetic Rat Model of Internalizing vs. Externalizing Behavior and Addiction Liability. bioRxiv. July 2022. (Hebda-Bauer, E.K., Hagenauer, M.H., Blandino, P., Jr., Meng, F., Chitre, A.S., Ozel, A.B., Arakawa, K., Flagel, S.B., Watson, S.J. Jr, Palmer, A, Li, J.Z., Akil, H.)
• Prenatal environmental stressors impair postnatal microglia function and adult behavior in males. Cell Rep. August 2022. (Block CL, Eroglu O, Mague SD, Smith CJ, Ceasrine AM, Sriworarat C, Blount C, Beben KA, Malacon KE, Ndubuizu N, Talbot A, Gallagher NM, Chan Jo Y, Nyangacha T, Carlson DE, Dzirasa K, Eroglu C, Bilbo SD.)
• Mitochondria DNA copy number, mitochondria DNA total somatic deletions, Complex I activity, synapse number, and synaptic mitochondria number are altered in schizophrenia and bipolar disorder. Transl Psychiatry. August 2022 (Das SC, Hjelm BE, Rollins BL, Sequeira A, Morgan L, Omidsalar AA, Schatzberg AF, Barchas JD, Lee FS, Myers RM, Watson SJ, Akil H, Bunney WE, Vawter MP.)
• Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling. Molecular Psychiatry. September 2022. (Arul Rayan NA, Kumar V, Aow J, Rastegar N, Lim MGL, O’Toole N, Aliwarga E, Arcego DM, Yeo HTG, Wong JY, Lee MY, Schmidt F, Haja HS, Tam WL, Zhang TY, Diorio J, Anacker C, Hen R, Parent C, Meaney MJ, Prabhakar S.)
• Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice. Sci Adv. October 2022. (Durand-de Cuttoli R, Martínez-Rivera FJ, Li L, Minier-Toribio A, Holt LM, Cathomas F, Yasmin F, Elhassa SO, Shaikh JF, Ahmed S, Russo SJ, Nestler EJ, Sweis BM.)
• DiffBrainNet: Differential analyses add new insights into the response to glucocorticoids at the level of genes, networks and brain regions. Neurobiol Stress. October 22. (Gerstner N, Krontira AC, Cruceanu C, Roeh S, Pütz B, Sauer S, Rex-Haffner M, Schmidt MV, Binder EB, Knauer-Arloth J.)
• Chronic stress and antidepressant treatment alter purine metabolism and beta oxidation within mouse brain and serum. Sci Rep. October 2022. (Hamilton PJ, Chen EY, Tolstikov V, Peña CJ, Picone JA, Shah P, Panagopoulos K, Strat AN, Walker DM, Lorsch ZS, Robinson HL, Mervosh NL, Kiraly DD, Sarangarajan R, Narain NR, Kiebish MA, Nestler EJ.)
• Enduring effects of early-life adversity on reward processes: A systematic review and meta-analysis of animal studies. Neurosci Biobehav Rev. November 2022. (Duque-Quintero M, Hooijmans CR, Hurowitz A, Ahmed A, Barris B, Homberg JR, Hen R, Harris AZ, Balsam P, Atsak P.)
• Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine. Biol Psychiatry. December 2022. (Carazo-Arias E, Nguyen PT, Kass M, Jee HJ, Nautiyal KM, Magalong V, Coie L, Andreu V, Gergues MM, Khalil H, Akil H, Arcego DM, Meaney M, Anacker C, Samuels BA, Pintar JE, Morozova I, Kalachikov S, Hen R.)
• The long noncoding RNA FEDORA is a cell type- and sex-specific regulator of depression. Scientific Advances. December 2022. (Issler O, van der Zee YY, Ramakrishnan A, Xia S, Zinsmaier AK, Tan C, Li W, Browne CJ, Walker DM, Salery M, Torres-Berrío A, Futamura R, Duffy JE, Labonte B, Girgenti MJ, Tamminga CA, Dupree JL, Dong Y, Murrough JW, Shen L, Nestler EJ.)
• Forebrain Glucocorticoid Receptor Overexpression Alters Behavioral Encoding of Hippocampal CA1 Pyramidal Cells in Mice. eNeuro. December 2022. (Gavade S, Wei Q, Johnston C, Kounelis-Wuillaume S, Laborc K, Baranwal S, Akil H, Spencer-Segal JL.)
• Brain-wide oscillatory network selectively encodes aggression. bioRxiv. December 2022. (Grossman YS, Talbot A, Gallagher NM, Thomas GE, Fink AJ, Walder-Christensen KK, Russo RJ, Carlson DE, Dzirasa.)