2023 HDRF Funded Research Publications

• Genome-Wide Association Study in a Rat Model of Temperament Identifies Multiple Loci for Exploratory Locomotion and Anxiety-Like Traits. Frontiers in Genetics. January 2023. ( Chitre, AS, Hebda-Bauer, EK, Blandino, P, Bimschleger, H, Nguyen, KM, Maras P, Li, F, Ozel, AB, Polesskaya, O, Cheng, R, Flagel, SB, Watson, SJ Jr., Li, J, Akil, H, Palmer, AA.)
• Effect of selective lesions of nucleus accumbens μ-opioid receptor-expressing cells on heroin self-administration in male and female rats: a study with novel Oprm1-Cre knock-in rats. J Neurosci. January 2023. (Bossert JM, Mejias-Aponte CA, Saunders T, Altidor L, Emery M, Fredriksson I, Batista A, Claypool SM, Caldwell KE, Reiner DJ, Chow JJ, Foltz M, Kumar V, Seasholtz A, Hughes E, Filipiak W, Harvey BK, Richie CT, Vautier F, Gomez JL, Michaelides M, Kieffer BL, Watson SJ, Akil H, Shaham Y.)
• Estradiol withdrawal following a hormone simulated pregnancy induces deficits in affective behaviors and increases ΔFosB in D1 and D2 neurons in the nucleus accumbens core in mice. Horm Behav. January 2023. (Foster WB, Beach KF, Carson PF, Harris KC, Alonso BL, Costa LT, Simamora RC, Corbin JE, Hoag KF, Mercado SI, Bernhard AG, Leung CH, Nestler EJ, Been LE.)
• Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes. Nat Commun. February 2023. (Fitzgerald E, Shen MJ, Yong HEJ, Wang Z, Pokhvisneva I, Patel S, O’Toole N, Chan S-Y, Seng CY, Chen H, Gluckman PD, Chan J, Lee P, Meaney MJ.)
• Functional connectivity mapping for rTMS target selection in depression. Am J Psychiatry. March 2023. (Elbau IG, Lynch CJ, Downar J, Vila-Rodriguez F, Power JD, Solomonov N, Daskalakis ZJ, Blumberger DM, Liston C.)
• Molecular and network-level mechanisms explaining individual differences in autism spectrum disorder. Nat Neurosci. April 2023. (Buch AM, Vertes PE, Seidlitz J, Kim SH, Grosenick L, Liston C.)
• Regulation of social interaction by a frontostriatal circuit modulated by established hierarchical relationships. Nat Commun. April 2023. (Fetcho RN, Hall BS, Estrin DJ, Walsh AP, Schuette PJ, Kaminsky J, Singh A, Roshgadol J, Bavley CC, Nadkarni V, Antigua S, Huynh TN, Grosenick L, Carthy C, Komer L, Adhikari A, Lee FS, Rajadhyaksha AM, Liston C.)
• Negative emotionality as a candidate mediating mechanism linking prenatal maternal mood problems and offspring internalizing behaviour. Dev Psychopathol. May 2023. (Green CG, Szekely E, Vanessa Babineau V, Jolicoeur-Martineau A, Bouvette-Turcot AA, Minde K, Sassi R, Atkinson L, Kennedy JL, Steiner M, Lydon J, Gaudreau H, Burack JA, Herba C, Pennestri M-H, Levitan R, Meaney MJ, Wazana A.)
• Monomethylation of Lysine 27 at Histone 3 (H3K27me1) confers lifelong susceptibility to stress. Neuron (Preprint). May 2023. (Torres-Berrio A, Estill M, Patel V, Ramakrishnan A, Kronman H, Minier-Toribio A, Issler O, Browne CJ, Parise EM, van der Zee Y, Walker D, Martinez-Rivera FJ, Lardner CK, Durand-de Cuttoli R, Russo SJ, Shen L, Sidoli S, Nestler EJ.)
• A Sex-Specific Genome-Wide Association Study of Depression Phenotypes in UK Biobank. Mol Psychiatry. June 2023. (Silveira PP, Pokhvisneva I, Howard DM, Meaney MJ.)
• Dopaminoceptive D1 and D2 neurons in ventral hippocampus arbitrate approach and avoidance in anxiety. bioRxiv. July 2023. (Godino, A., Salery, M., Minier-Toribio, A.M., Patel, V., Fullard, J.F Parise, EM, Martinez-Rivera FJ, Morel C, Roussos P, Blitzer RD, Nestler EJ)
• Anandamide hydrolysis inhibition modulates stress markers via beta-cateinin in the PFC in a rat model of PTSD. Prog Neurobiol. July 2023. (Portugalov A, Sbarski B, Nestler EJ, Parise E, Akirav I, Zer-Aviv TM.)
• Extensive evaluation of DNA methylation of functional elements in the murine Fkbp5 locus using high-accuracy DNA methylation measurement via targeted bisulfite sequencing. Eur J Neurosci. August 2023. (Yusupov N, van Doeselaar L, Röh S, Wiechmann T, Ködel M, Sauer S, Rex-Haffner M, Schmidt MV, Binder EB.)
• Cingulate dynamics track depression recovery with deep brain stimulation. Nature. October 2023. (Alagapan A, Choi KS, Heisig S, Rivaposse P, Crowell A, Tiruvadi V, Obatusin M, Veerkumar A, Waters A, Gross R, Quinn S, Denison L, Oshaughnessy M, Connor M, Canal G, Cha J, Herschenberg R, Nauvel T, Isbaine F, Afzal MF, Figee M, Kopell B, Butera R, Mayberg H, Rozell C.)
• Cell-type-specific aging effects in the human OFC and implications for psychiatric disease. European Neuropsychopharmacology. October 2023. (Fröhlich AS, Gerstner N, Gagliardi M, Ködel M, Yusupov N, Matosin N, Czamara D, Sauer S, Roeh S, Murek V, Chatzinakos C, Daskalakis NP, Knauer-Arloth J, Ziller MJ, Binder EB.)
• High-throughput screening of glucocorticoid-induced enhancer activity reveals mechanisms of stress-related psychiatric disorders. Proc Natl Acad Sci USA. December 2023. (Penner-Goeke S, Bothe M, Rek N, Kreitmaier P, Pöhlchen D, Kühnel A, Glaser LV, Kaya E, Krontira AC, Röh S, Czamara D, Ködel M, Monteserin-Garcia J, Diener L, Wölfel B, Sauer S, Rummel C, Riesenberg S, Arloth-Knauer J, Ziller M, Labeur M, Meijsing S, Binder EB.)
• Transcriptional dissection of symptomatic profiles across the brain of men and women with MDD. Nat. Commun. October 2023. (Mansouri S, Pessoni AM, Rivera AM, Parise E, Tamminga CA, Turecki G, Nestler EJ, Chen TH, Labonté B.)
• The neurobiology of stress: Vulnerability, resilience, and major depression. Proc. Natl. Acad. Sci. USA. December 2023. (Akil H, Nestler EJ.)
• A translational polygenic score of biological sensitivity to context. Am J Psychiatry. 2023. (Latsko MS, Wang Z, Zhang TY, Parent C, O’Toole N, Pokhvisneva I, Kee MZL, Wen X, Craig K, Boyce WT, Meaney MJ, Silveira PP.)
• A genetic proxy of microglial function modulates the relation between depression risk factors and depression outcomes throughout life in females. Mol Psychiatry. 2023 (Fitzgerald E, Pokhvisneva I, Patel S, Chan SY, Tan AP, Chen H, Silveira PP, Meaney MJ.)