2024 HDRF Funded Research Publications

• A glucocorticoid-sensitive hippocampal gene network moderates the impact of early life adversity on mental health outcomes. Biological Psychiatry. January 2024. (Arcego DM, Buschdorf J-P, O’Toole N, Wang Z, Barth B, Pokhvisneva I, Arul Rayan N, Patel S, Mendonça Filho E, Lee P, Jennifer Tan J, Ming Xuan Koh MX, Sim CM, Parent C, Merscher R, Clappison A, O’Donnell KJ, Dalmaz C, Arloth J, Provençal N, Binder EB, Diorio J, Silveira PP, Meaney MJ)
• Whole Brain Network effects of subcallosal cingulate deep brain stimulation for treatment-resistant depression. Molecular Psychiatry. January 2024. (Cha J, Choi KS, Rajendra J, McGrath CL, Holtzheimer PE, Riva-Posse P, Mayberg H.)
• Advancing preclinical chronic stress models to promote therapeutic discovery for human stress disorders. Neuropsychopharmacology. January 2024. (Gyles TM, Nestler EJ, and Parise EM.)
• Electronvulsive therapy-a shocking inducer of neuroplasticity? Mol Psychiatry. January 2024. (Tartt AN, Mariani M, Hen R, Mann JJ, Boldrini M.)
• DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans. Mol Psychiatry. February 2024. (Yusupov N, Roeh S, Sotillos Elliott L, Chang S, Loganathan S, Urbina-Treviño L, Fröhlich AS, Sauer S, Ködel M, Matosin N, Czamara D, Deussing JM, Binder EB.)
• In Vitro Functional Profiling of Fentanyl and Nitazene Analogs at the μ-Opioid Receptor Reveals High Efficacy for Gi Protein Signaling. ACS Chem Neurosci. February 2024. (Tsai MM, Chen L, Baumann MH, Canals M, Javitch JA, Lane JR, Shi L.)
• A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior. Neuron. February 2024. (Fetcho RN, Parekh PK, Chou J, Kenwood M, Chalençon L, Estrin DJ, Johnson M, Liston C.)
• Circulating myeloid-derived MMP8 in stress susceptibility and depression. Nature. February 2024. (Desland F, Shimo Y, Ramakrishnan A, Estill M, Ferrer-Perez C, Parise EM, Wilk CM, Kaster MP, Wnag J, Sowa A, Janssen WG, Costi S, Rahman A, Fernandez M, Campbell M, Swirski FK, Nestler EJ, Shen L, Merad M, Murrough JW, Russo SJ.)
• Early-life stress alters chromatin modifications in VTA to prime stress sensitivity. bioRxiv. March 2024. (Geiger LT, Balouek JA, Farrelly LA, Chen AS, Tang M, Bennett SN, Nestler EJ, Garcia BA, Maze I, Peña CJ)
• RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine. Mol. Pharmacol. March 2024. (Mitsi V, Ruiz A, Polizu C, Farzinpour Z, Ramakrishnan A, Serafini RA, Parise EM, Floodstrand M, Sial OK, Gaspari S, Tang CY, Nestler EJ, Schmidt EF, Shen L, Zachariou V.)
• Effects of electroconvulsive shock on the funnction, circuitry, and trasncriptome of dentate gyrus granule neurons. bioRxiv. March 2024. (Santiago AN, Castello-Saval J, Nguyen P, Chung HM, Luna VM, Hen R, Chang WL.)
• Switching on generalized fear. Science. March 2024. (Hen R, Schacher S.)
• A revamped rat reference genome improve the discovery of genetic diversity in laboratory rats. Cell Genomics. April 2024. (de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H.)
• Sex-Specific Regulation of Stress Susceptibility by the Astrocytic Gene Htra1. bioRxiv. April 2024. (Parise EM, Gyles TM, Godino A, Sial OK, Browne CJ, Parise LF, Torres-Berrío A, Salery M, Durand-de Cuttoli R, Rivera MT, Cardona-Acosta AM, Holt L, Markovic T, van der Zee YY, Lorsch ZS, Cathomas F, Garon JB, Teague C, Issler O, Hamilton PJ, Bolaños-Guzmán CA, Russo SJ, Nestler EJ.)
• Molecular Design of SERTlight: A Fluorescent Serotonin Probe for Neuronal Labeling in the Brain. J Am Chem Soc. April 2024. (Lee WL, Westergaard X, Hwu C, Hwu J, Fiala T, Lacefield C, Boltaev U, Mendieta AM, Lin L, Sonders MS, Brown KR, He K, Asher WB, Javitch JA, Sulzer D, Sames D.)
• Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression. Neuron. May 2024. (Krontira AC, Cruceanu C, Dony L, Kyrousi C, Link MH, Rek N, Pöhlchen D, Raimundo C, Penner-Goeke S, Schowe A, Czamara D, Lahti-Pulkkinen M, Sammallahti S, Wolford E, Heinonen K, Roeh S, Sportelli V, Wölfel B, Ködel M, Sauer S, Rex-Haffner M, Räikkönen K, Labeur M, Cappello S, Binder EB.)
• Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype. Neurobiology Stress. May 2024. (O’Connor AM, Hagenauer MH, Forrester LCT, Maras PM, Arakawa K, Hebda-Bauer EK, Khalil H, Richardson ER, Rob FI, Sannah Y, Watson SJ Jr, Akil H.)
• Promiscuous G-protein activation by the calcium-sensing receptor. Nature. May 2024. (Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR.)
• An internal brain state encodes goal proximity across contexts. In prep, submission date, June 2024. (Vu MT, Talbot A, Walder-Christensen KK, David LK, Thomas GE, Adamson E, Vagwala M, Lane CB, Gallagher NM, Wang J, Blount C, Hughes DN, Calvo S, Sweis B, Mague SD, Adcock RA, Carlson D, Dzirasa K.)
• A widespread electrical brain network encodes anxiety in health and depressive states. bioRxiv. June 2024. (Hughes DN, Klein MH, Walder-Christensen KK, Thomas  GE, Grossman Y, Waters D, Matthews AE, Carson WE, Filali Y, Tsyglakova M, Fink A, Gallagher NM, Perez-Balaguer M, McClung CA, Zarate JM, Hultman RC, Mague SD, Carlson DE, Dzirasa K.)
• A curated database of brain-related functional gene sets (Brain.GMT). MethodsX. June 2024. (Hagenauer MH, Sannah Y, Hebda-Bauer EK, Rhoads C, O’Connor AM, Flandreau E, Watson SJ Jr, Akil H.)
• A double-hit of social and economic stress in mice precipitates changes in decision-making strategies. Biol. Psychiatry. July 2024. (Durand-de Cuttol R, Martínez-Rivera FJ, Li L, Minier-Toribio A, Dong Z, Cai DJ, Russo SJ, Nestler EJ, Sweis BM.)
• Multi-omic profiling of transcription factor binding and function in human brain. Nature Neuroscience. July 2024. (Loupe, JM, Anderson AG, Rizzardi LF, Rodriguez-Nunez I, Moyers B, Trausch-Lowther K, Jain R, Bunney WE, Bunney BG, Cartagena P, Sequeira A, Watson SJ, Akil H, Cooper GM, Myers, RM.)
• Adult Neurogenesis, Context Encoding, and Pattern Separation: A Pathway for Treating Overgeneralization. Avd Neurobiol. July 2024. (Chang WL, Hen R.)
• Allele-specific transcription factor binding across human brain regions offers mechanistic insight into eQTLs. Genome Res. September 2024. (Anderson AG, Moyers BA, Loupe JM, Rodriguez-Nunez I, Felker SA, Lawlor JMJ, Bunney WE, Bunney BG, Cartagena PM, Sequeira A, Watson SJ, Akil H, Mendenhall EM, Cooper GM, Myers RM.)
• Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models. Nat Commun. September 2024. (Havel V, Kruegel AC, Bechand B, McIntosh S, Stallings L, Hodges A, Wulf MG, Nelson M, Hunkele A, Ansonoff M, Pintar JE, Hwu C, Ople RS, Abi-Gerges N, Zaidi SA, Katritch V, Yang M, Javitch JA, Majumdar S, Hemby SE, Sames D.)
• Frontostriatal salience network expansion in individuals in depression. Nature. September 2024. (Lynch CJ, Elbau IG, Ng T, Ayaz A, Zhu S, Wolk D, Manfredi N, Johnson M, Chang M, Chous J, Summerville I, Ho C, Lueckel M, Bukhari H, Buchanan D, Victoria LW, Solomonov N, Goldwaser E, Moia S, Caballero-Gaudes C, Downar J, Vila-Rodriguez F, Daskalakis ZJ, Nlumberger DM, Kay K, Aloysi A, Gordon EM, Bhati MT, Williams N, Power JD, Zebley B, Grosenick L, Gunning FM, Liston C.)
• Dimensional and categorical solutions to parsing depression heterogeneity in a large single-site sample. Biological Psychiatry. September 2024. (Dunlop K, Grosenick L, Downar J, Dakalakis ZJ, Blumberger DM, Liston C.)
• Single-nucleus transcriptomic profiling of human orbitofrontal cortex reveals convergent effects of aging and psychiatric disease. Nat Neurosci. October 2024. (Fröhlich AS, Gerstner N, Gagliardi M, Ködel M, Yusupov N, Matosin N, Czamara D, Sauer S, Roeh S, Murek V, Chatzinakos C, Daskalakis NP, Knauer-Arloth J, Ziller MJ, Binder EB.)
• Elucidating the molecular logic of a metabotropic glutamate receptor heterodimer. Nat Commun. October 2024. (Lin X, Provasi D, Niswender CM, Asher WB, Javitch JA.)
• Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice. Biol Psychiatry Glob Open Sci. November 2024. (Chang WL, Tegang K, Samuels BA, Saxe M, Wichmann J, David DJ, David IM, Augustin A, Fischer H, Golling S, Lamerz J, Roth D, Graf M, Zoffmann S, Santarelli L, Jagasia R, Hen R.)