2025 HDRF Funded Research Publications

• Optimal sparsity in autoencoder memory models of the hippocampus. bioRxiv (Preprint). January 2025. (Shah A, Hen R, Losonczy A, Fusi S.)
• Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoids. bioRxiv. Ferbuary 2025. (Dony L, Krontira AC, Kaspar L, Ahmad R, Demirel IS, Grochowicz M, Schäfer T, Begum F, Sportelli V, Raimundo C, Koedel M, Labeur M, Cappello S, Theis FJ, Cruceanu C, Binder EB.)
• Antidepressants reactivate developmental plasticity through remodeling of extracellular matrix. bioRxiv (Preprint). February 2025. (Nguyen PT, Tamura S, Sun E, Shi Y, Xiao Y, Lacefield C, Turi GF, Hen R.)
• Synaptic Vesical 2A (SV2A) Positron Emission Tomography (PET) Imaging as a Marker of Therapeutic Response. bioRxiv. February 2025. (Corvo C, Mendez- David I, Goutal S, Saba W, Bottlaender M, Caille F, Hen R.)
• N-terminal fragment shedding contributes to signaling of the full-length adhesion receptor ADGRL3. J Biol Chem. February 2025. (Perry-Hauser NA, Du Rand JR, Lee KH, Shi L, Javitch JA.)
• Contrasting genetic predisposition and diagnosis in psychiatric disorders: A multi-omic single-nucleus analysis of the human OFC. Science Advances. March 2025. (Gerstner N, Fröhlich AS, Matosin N, Gagliardi M, Cruceanu C, Ködel M, Rex-Haffner M, Tu X, Mostafavi S, Ziller MJ, Binder EB, Knauer-Arloth J.)
• Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament. Front Mol Neurosci. March 2025. (Hebda-Bauer EK, Hagenauer MH, Munro DB, Blandino P Jr, Meng F, Arakawa K, Stead JDH, Chitre AS, Ozel AB, Mohammadi P, Watson SJ Jr, Flagel SB, Li J, Palmer AA, Akil H.)
• Synaptic editing of frontostriatal circuitry prevents excessive grooming in SAPAP3-deficient mice.  bioRxiv (Preprint). March 2025. (Walder-Christensen K, Soliman H, Calakos N, Dzirasa K.)
• Promoting Open Discussions of Scientific Failure within the Annual Society for Neuroscience Conference. eNeuro. March 2025. (Hagenauer MH, David Redish A, Schiller D, Bigos KL, Flagel S, Rodriguez A, Parker Z, O’Connor A, Ortiz-Gonzalez X, Murphy D, Leeson R; Community for Rigor.)
• The Effects of Antidepressants on the Hippocampus: A Meta-Analysis of Public Transcriptional Profiling Data. bioRxiv (Preprint). April 2025. (Geoghegan EM, Hagenauer MH, Hernandez E, Espinoza S, Flandreau EI, Nguyen PT, Bhuiyan MR, Mensch S, Watson Jr. SJ, Akil H, Hen R.)
• A rare variant in GPR156 Associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice. Proc Natl Acad Sci USA. April 2025. (Miller BR, Gonzaga-Jauregui C, Brigatti KW, de Jong J, Breese RS, Ko SY, Puffenberger EG, Van Hout C, Young M, Luna VM, Staples J, First MB, Greogoire HJ, DWork AJ, Pefanis E, McCarthy S, Brydges S, Rojas J, Ye B, Stahl E, Di Gioia SA, Hen R, Elwood K, Rosoklija G, Li D, Mellis S, Carey D, Croll SD, Overton JD, Macdonald LE, Economides AN, Shuldiner AR, Chuhma N, Raport S, Amin N, Kushner SA, Alessandri-Haber N, Markx S, Strauss KA.)
• Chronic administration of methocinnamox, a mu-opioid receptor antagonist, reduces hedonic response without impacting motivation in mice. Psychopharmacology (Berl). May 2025. (Sheikh M, Cambre E, Langreck C, Javitch JA, Canetta SE.)
• Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress. Biol Psychiatry. May 2025. (Holt LM, Gyles TM, Parise EM, Minier-Toribio A, Markovic T, Rivera M, Yeh SY, and Nestler EJ.)
• A meta-analysis of the effects of early life stress on the prefrontal cortex transcriptome reveals long-term down-regulation of myelin-related gene expression. Brain and Behavior. June 2025. (Duan TQ, Hagenauer MH, Flandreau EI, Bader A, Nguyen DM, Maras PM, De Lima RMS, Gyles T, Mclain C, Meaney MJ, Nestler EJ, Watson SJ Jr, Akil H.)
• Cell-type specific reductions in interneuron gene expression within the cingulate gyrus of schizophrenia and bipolar subjects. Schizophrenia. June 2025. (Krolewski, DM, Khalil H, Waselus M, Vawter MP. Bunney BG, Myers RM, Lee FS, Schatzberg AF, Bunney WE, Akil H, Watson SJ, Jr.)
• Dopaminergic D1 and D2 transmission in ventral hippocampus arbitrates approach and avoidance. Nature. July 2025. (Godino A, Salery M, Minier-Toribo AM, Patel V, Fullard JF, Kondev V, Parise EM, Martinez-Rivera FJ, Morel C, Roussos P, Blitzer RD, Nestler EJ).
• Change-of-mind neuroeconomic decision-making is modulated by LINC00473 in medial prefrontal cortex in a sex-dependent manner. Sci Adv. July 2025. (Durand-de Cuttoli R, Issler O, Pedersen SMB, Yakubov B, Jahan N, ABid A, Kasparov S, Granizo K, Ahmed S, Russo SJ, Nestler EJ, Sweis BM.)
• A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models. bioRxiv. (Preprint). August 2025. (Rhoads CA, Hagenauer MH, Xiong J, Hernandez E, Nguyen DM, Saffron A, Flandreau EIF, Watson Jr. SJ, Akil H.)
• Male and female variability in response to chronic stress and morphine in C57B/6J, DBA, and BXD mouse lines. Sci. Rep. 2025. (Morel C, Parise LF, van der Zee Y, Issler O, Cai M, Browne C, Blando A, Leclair K, Haynes S, Williams RW, Mulligan MK, Russo SJ, Nestler EJ, Han MH.)
• Ventral CA1 Population Codes for Anxiety. Neuron (In revision). 2025. (Lim SC, Lacefield CO, Chang WIL, Chung H, Horowitz A, Fusi S, Hen R.)