2017 HDRF funded Research Publications

Treatment Resistant Depression: A Multi-scale, Systems Biology Approach. 2017. (Akil H., Gordon J., Hen R., Javitch J., Mayberg H., McEwen B., Meaney M., Nestler E.)

Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life. Neuropsychopharmacology. March 2017. (Prater K.E., Aurbach E.L., Larcinese H.K., Smith T.N., Turner C.A., Blandino Jr. P, Watson S.J., Maren S., Akil H.)

Adolescent cocaine exposure enhances goal-tracking behavior and impairs hippocampal cell genesis selectively in adult bred low-responder rats. Psychopharmacology (Berl). April 2017. (García-Fuster M.J., Parsegian A., Watson S.J., Akil H., Flagel S.B.)

The role of individual differences in response to stress, fear conditioning and drugs of abuse. Current Opinion in Behavioral Sciences. In Press, 2017. (Turner C.A., Flagel S.B., Blandino Jr. P., Watson S.J., Akil H.)

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu Opioid Receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017. (Samuels B.A., Nautiyal K.M., Kruegel A.C., Levinstein M.R., Magalong V.M., Gassaway M.M., Grinnell S.G., Han J., Ansonoff M.A., Pintar J.E., Javitch J.A., Sames D., and Hen R.)

Serotonin receptors in depression: from A to B. F1000Res. February 2017. (Nautiyal K.M., Hen R.)

Being Open Minded about Neuromodulation Trials: Finding Success in our Failures. Brain Stimulation. 2017. (Fins J.J., Kubu C.S., Mayberg H.S., Merkel R., Nuttin, B., and Schlaepfer T.E.)

A Computational Model of Major Depression: the Role of Glutamate Dysfunction on Cingulo-Frontal Network Dynamics. Cereb Cortex. January 2017. (Ramirez-Mahaluf J.P., Roxin A., Mayberg H.S., Compte A.)

Deep Brain Stimulation. Psychiatry New Oxford Textbook of Psychiatry. In press, March 2017. (Crowell A., Riva Posse P., Mayberg H.S.)

A connectomic approach for subcallosal cingulate deepbrain stimulation surgery: prospective targeting in treatment-resistant depression. Molecular Psychiatry. 2017. (Riva-Posse P., Choi K.S., Holtzheimer P.E., Crowell A.L., Garlow S.J., Rajendra J.K., McIntyre CC., Gross RE. and Mayberg H.S.)

Translational profiling of stress-induced neuroplasticity in the CA3 pyramidal neurons of BDNF Val66Met mice. Molecular Psychiatry. 2017. (Gray, J.G., Rubin, T.G., Kogan, J.F., Marrocco J., Weidmann J., Lindkvist S., Lee F.S., Schmidt, E.F., McEwen, B.S.)

Stress-induced structural plasticity of medial amygdala stellate neurons and rapid prevention by a candidate antidepressant. Molecular Psychiatry. 2017. (Lau T., Bigio B., Zelli D., McEwen B.S., Nasca C.)

Fetal origins of mental health: The Developmental Origins of Health and Disease Hypothesis. American Journal of Psychiatry. 2017. (O’Donnell K.J., Meaney M.J.)

Tet1 in nucleus accumbens opposes depression-and anxiety-like behaviors. Neuropsychopharmacology. In press 2017. (Feng J., Peña C.J., Purushothaman I., Engmann O., Walker D., Brown A.N., Issler O., Doyle M., Harrigan E., Mouzon E., Vialou V., Shen L., Dawlaty M.M., Jaenisch R., and Nestler E.J.)

Ventral hippocampal neurons projecting to hypothalamus mediate innate fear behavior. Submitted. (Jimenez J.C., Goldberg A., Su K., Luna V., Ordek G., Pena S., Ong S., Zweifel L., Hen R., and Kheirbek M.A.)

The importance of correlated neuronal activity for spatial coding in mouse dentate gyrus granule cells. Submitted. (Stefanini F., Kheirbek M., Kushnir L., Jennings J., Ramakrishnan C., Deisseroth K., Stuber G., Hen R., Fusi S.)

Adult hippocampal neurogenesis and cognitive flexibility – linking memory and mood. Nature Review Neuroscience. In press. (Anacker C., and Hen R.)

Early life stress results in persistent changes in the translational profile of CA3 neurons and alters future stress reactivity. (in preparation) (Gray JD., Kogan J.F., Rubin T.G., Marrocco J., Schmidt E., McEwen B.S.)

A sexually dimorphic “pre-stressed” translational signature in CA3 pyramidal neurons of BDNFVal66Met mice. (Under revision) (Marrocco J., Petty G.H., Ríos M.B., Gray J.D., Kogan J.F., Waters E.M., Schmidt E.F., Lee F.S., McEwen B.S.)